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Oesophagostomum dentatum — Potential as a model for genomic studies of strongylid nematodes, with biotechnological prospects

Paper ID Volume ID Publish Year Pages File Format Full-Text
14836 1258 2007 13 PDF Available
Title
Oesophagostomum dentatum — Potential as a model for genomic studies of strongylid nematodes, with biotechnological prospects
Abstract

There are substantial gaps in the knowledge of the molecular processes of development and reproduction in parasitic nematodes, despite the fact that understanding such processes could lead to novel ways of treating and controlling parasitic diseases, through blocking or disrupting key biological pathways. Biotechnological advances through large-scale sequencing projects, approaches for the analysis of differential gene and protein expression and functional genomics (e.g., double-stranded RNA interference) now provide opportunities to investigate the molecular basis of developmental processes in some parasitic nematodes. The porcine nodule worm, Oesophagostomum dentatum (order Strongylida), may provide a platform for testing the function of genes from this and related nematodes, given that this species can be grown and maintained in culture in vitro for periods longer than other nematodes of the same order. In this article, we review relevant biological, biochemical and molecular biological and genomic information about O. dentatum and propose that the O. dentatum — pig system provides an attractive model for exploring molecular developmental and reproductive processes in strongylid nematodes, leading toward new intervention methods and biotechnological outcomes.

Keywords
Oesophagostomum dentatum (Nematoda: Strongylida); Parasitic nematodes; Genomics; Development; Reproduction; Caenorhabditis elegans
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Oesophagostomum dentatum — Potential as a model for genomic studies of strongylid nematodes, with biotechnological prospects
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 25, Issue 3, May–June 2007, Pages 281–293
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us