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Protein secretion pathways in Bacillus subtilis: Implication for optimization of heterologous protein secretion

Paper ID Volume ID Publish Year Pages File Format Full-Text
14843 1264 2007 12 PDF Available
Title
Protein secretion pathways in Bacillus subtilis: Implication for optimization of heterologous protein secretion
Abstract

The absence of an outer membrane in Bacillus subtilis can simplify the protein secretion pathways and allow the organism to secrete high levels of extracellular proteins. Of the three known secretory routes, Sec-SRP pathway can direct the majority of secretory proteins into the growth medium. Alternatively, a small number of exoproteins with specific functions are secreted via Tat pathway or ABC transporters in B. subtilis. The discriminating function of precursor proteins among these pathways is largely attributed to the distinct structure of their cleavable signal peptides. Individual secretion machinery components with their special functions are involved in the total flow of proteins from the cytoplasm to the medium. Notably, multiple regulators with signal transduction functions can affect expression of secretion machinery as well as their post-transcriptional actions for protein secretion, resulting in the complicated networks in B. subtilis. Ultimately, according to the available knowledge of secretion machinery, several approaches aimed at optimizing protein secretion are discussed.

Keywords
ABC, ATP-binding cassette; AmyQ, Bacillus amyloliquefaciens α-amylase; AP, alkaline phosphatase; BLA, Bacillus licheniformis α-amylase; CWB, cell wall-binding repeat; EAA, glutamate–alanine–alanine; Ffh, fifty-four homolog; FNLDV, phenylalanine–asparagine
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Protein secretion pathways in Bacillus subtilis: Implication for optimization of heterologous protein secretion
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 25, Issue 1, January–February 2007, Pages 1–12
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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