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Endless versatility in the biotechnological applications of Kluyveromyces LAC genes

Paper ID Volume ID Publish Year Pages File Format Full-Text
14875 1278 2006 14 PDF Available
Title
Endless versatility in the biotechnological applications of Kluyveromyces LAC genes
Abstract

Most microorganisms adapted to life in milk owe their ability to thrive in this habitat to the evolution of mechanisms for the use of the most abundant sugar present on it, lactose, as a carbon source. Because of their lactose-assimilating ability, Kluyveromyces yeasts have long been used in industrial processes involved in the elimination of this sugar. The identification of the genes conferring Kluyveromyces with a system for permeabilization and intracellular hydrolysis of lactose (LAC genes), along with the current possibilities for their transfer into alternative organisms through genetic engineering, has significantly broadened the industrial profitability of lactic yeasts. This review provides an updated overview of the general properties of Kluyveromyces LAC genes, and the multiple techniques involving their biotechnological utilization. Emphasis is also made on the potential that some of the latest technologies, such as the generation of transgenics, will have for a further benefit in the use of these and related genes.

Keywords
LAC4; LAC12; Kluyveromyces; Cheese whey; Lactose; β-galactosidases
First Page Preview
Endless versatility in the biotechnological applications of Kluyveromyces LAC genes
Publisher
Database: Elsevier - ScienceDirect
Journal: Biotechnology Advances - Volume 24, Issue 2, March–April 2006, Pages 212–225
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering