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A model for the clustered distribution of SNPs in the human genome

Paper ID Volume ID Publish Year Pages File Format Full-Text
14889 1360 2016 5 PDF Available
Title
A model for the clustered distribution of SNPs in the human genome
Abstract

•A phenomenological model is introduced to account for clustering properties of SNPs.•The model is based on a preferential mutation to the closer proximity of other SNPs.•The model is applicable not only to autosomes but also to the X chromosome.•The model supports the mutational non-independence hypothesis.

Motivated by a non-random but clustered distribution of SNPs, we introduce a phenomenological model to account for the clustering properties of SNPs in the human genome. The phenomenological model is based on a preferential mutation to the closer proximity of existing SNPs. With the Hapmap SNP data, we empirically demonstrate that the preferential model is better for illustrating the clustered distribution of SNPs than the random model. Moreover, the model is applicable not only to autosomes but also to the X chromosome, although the X chromosome has different characteristics from autosomes. The analysis of the estimated parameters in the model can explain the pronounced population structure and the low genetic diversity of the X chromosome. In addition, correlation between the parameters reveals the population-wise difference of the mutation probability. These results support the mutational non-independence hypothesis against random mutation.

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Keywords
Single nucleotide polymorphism; Mutation; Human genome; Probability distribution; Hapmap
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A model for the clustered distribution of SNPs in the human genome
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 64, October 2016, Pages 94–98
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Online Support
Any Questions? feel free to contact us