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Identification of miRNAs and their targets involved in the secondary metabolic pathways of Mentha spp.

Paper ID Volume ID Publish Year Pages File Format Full-Text
14896 1360 2016 9 PDF Available
Title
Identification of miRNAs and their targets involved in the secondary metabolic pathways of Mentha spp.
Abstract

•Eleven miRNAs families and 130 target transcripts were identified.•Predicted miRNAs were involved in different metabolic process.•miR156, miR414 and miR5021 showed regulation of essential oil biosynthesis.•Three miRNAs were involved in trichome development.

The endogenous, small and non-coding functional microRNAs govern the regulatory system of gene expression and control the growth and development of the plants. Mentha spp. are well known herbs for its flavor, fragrance and medicinal properties. In the present study, we used a computational approach to identify miRNAs and their targets involved in different secondary metabolic pathways of Mentha spp. Additionally, phylogenetic and conservation analysis were also done for the predicted miRNAs. Eleven miRNAs families were identified from Mentha spp., out of which five miRNA families were reported for the first time from Lamiaceae. Overall, 130 distinct target transcripts were predicted for eight miRNAs families. All the predicted targets regulated by predicted miRNAs control the reproduction, signaling, stimulus response, developmental and different metabolic process. miRNA mediated gene regulatory network was also constructed on the basis of hybridized minimum free energy of identified miRNAs and their targets. The study revealed that the gene regulatory system of essential oil biosynthesis may be governed by miR156, miR414 and miR5021 in mint family. Furthermore, three miRNA candidates (miR156, miR5021, and miR5015b) were observed to be involved in trichome development also. This is the first in-silico study describing miRNAs and their role in the regulation of secondary metabolic pathways in Mentha spp.

Graphical abstractThe study revealed that essential oil biosynthesis in Mentha spp. may be governed by miR156, miR414 and miR5021. Three miRNA candidates (miR156, miR5021, and miR5015b) were observed to be involved in trichome development. This is the first in-silico study describing miRNAs and their role in the regulation of secondary metabolic pathways in Mentha spp.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
miRNA-targets; Secondary metabolic process; Essential oil biosynthesis; Trichome development; Mentha
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Identification of miRNAs and their targets involved in the secondary metabolic pathways of Mentha spp.
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 64, October 2016, Pages 154–162
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us