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On origin and evolution of carbonic anhydrase isozymes: A phylogenetic analysis from whole-enzyme to active site

Paper ID Volume ID Publish Year Pages File Format Full-Text
14936 1362 2016 9 PDF Available
Title
On origin and evolution of carbonic anhydrase isozymes: A phylogenetic analysis from whole-enzyme to active site
Abstract

•Phylogenetic analysis of isozymes of carbonic anhydrase family was carried out.•Kingdom-specificity of the members of the family was explored.•All the members of the family were discovered to be present in all three forms of life.•Evolution of active site across different classes of the members was carried out.•Similarity of sequences in the proximity of Zn ion was proposed to be responsible for functional similarity.

Genetic evolution of carbonic anhydrase enzyme provides an interesting instance of functional similarity in spite of structural diversity of the members of a given family of enzymes. Phylogenetic analysis of α-, β- and γ-carbonic anhydrase was carried out to determine the evolutionary relationships among various members of the family with the enzyme marking its presence in a wide range of cellular and chromosomal locations. The presence of more than one class of enzymes in a particular organism was revealed by phylogenetic time tree. The evolutionary relationships among the members of animal, plant and microbial kingdom were developed. The study revises a long-established notion of kingdom-specificity of the different classes of carbonic anhydrases and provides a new version of the presence of multiple classes of carbonic anhydrases in a single organism and the presence of a given class of carbonic anhydrase across different kingdoms.

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Keywords
Kingdom-specificity; Active site; Sequence alignment; Carbonic anhydrases; Biological function; Structural similarity
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On origin and evolution of carbonic anhydrase isozymes: A phylogenetic analysis from whole-enzyme to active site
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 61, April 2016, Pages 121–129
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
You save - $31
Price after discount Only $4.95
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