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Genome-wide evidence of positive selection in Bacteroides fragilis

Paper ID Volume ID Publish Year Pages File Format Full-Text
14994 1366 2014 8 PDF Available
Title
Genome-wide evidence of positive selection in Bacteroides fragilis
Abstract

•We identified 1275 orthologous gene clusters present in all eight Bacteroides genomes.•52 genes were identified as being under positive selection in the Bacteroides fragilis lineage.•Many genes involved in the cell surface/membrane exhibited positive selection.•Positively selected proteins in B. fragilis might interact with host immune systems.

We used an evolutionary genomics approach to identify genes that are under lineage-specific positive selection in six species of the genus Bacteroides, including three strains of pathogenic Bacteroides fragilis. Using OrthoMCL, we identified 1275 orthologous gene clusters present in all eight Bacteroides genomes. A total of 52 genes were identified as under positive selection in the branch leading to the B. fragilis lineage, including a number of genes encoding cell surface proteins such as TonB-dependent receptor. Three-dimensional structural mapping of positively selected sites indicated that many residues under positive selection occur in the extracellular loops of the proteins. The adaptive changes in these positively selected genes might be related to dynamic interactions between the host immune systems and the surrounding intestinal environment.

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Keywords
Bacteroides fragilis; Molecular evolution; Positive selection; Pathogenicity
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Genome-wide evidence of positive selection in Bacteroides fragilis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 52, October 2014, Pages 43–50
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
You save - $31
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Full-text PDF Download
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