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CAMWI: Detecting protein complexes using weighted clustering coefficient and weighted density

Paper ID Volume ID Publish Year Pages File Format Full-Text
15023 1367 2015 10 PDF Available
Title
CAMWI: Detecting protein complexes using weighted clustering coefficient and weighted density
Abstract

•A method for detecting protein complex in a core-attachment structure is proposed•It uses effectively protein–protein interaction’s weight•Weighted clustering coefficients is used to find protein complex’s seed•It finds the protein complexes with high weighted density in their cores

Detection of protein complexes is very important to understand the principles of cellular organization and function. Recently, large protein–protein interactions (PPIs) networks have become available using high-throughput experimental techniques. These networks make it possible to develop computational methods for protein complex detection. Most of the current methods rely on the assumption that protein complex as a module has dense structure. However complexes have core-attachment structure and proteins in a complex core share a high degree of functional similarity, so it expects that a core has high weighted density. In this paper we present a Core-Attachment based method for protein complex detection from Weighted PPI Interactions using clustering coefficient and weighted density. Experimental results show that the proposed method, CAMWI improves the accuracy of protein complex detection.

Keywords
Protein complex; Core-attachment structure; Clustering coefficient; Graph weighted density
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 58, October 2015, Pages 231–240
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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