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Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
1508 85 2009 8 PDF Available
Title
Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications
Abstract

Injectable acrylamide/N-vinylpyrrolidinone copolymers with pendent thiol groups were prepared by a radical polymerization and reductive dissolution reaction. The solution of copolymers was re-gelled through oxidation in air or the thiol–disulfide exchange reaction. The re-gelation time could be adjusted from several minutes to several hours by changing the amount of the disulfide exchange reagent. The re-gelled hydrogels possessed high transmittance in the visible region but could block out some of the ultraviolet radiation. Their refractive indexes ranged from 1.34 to 1.35, and their equilibrium water contents were over 95.0%. The morphologies of the hydrogels were analyzed and the porous structure, with pore sizes of 50–300 μm, was noted. The cytotoxicities of the hydrogels were clearly reduced compared with previous results. The experimental results indicated that the injectable copolymers could be used as an artificial vitreous substance or as a scaffold for lens regeneration.

Keywords
Disulfide bond; Hydrogel; Vitreous substance; Lens regeneration
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Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 4, May 2009, Pages 1056–1063
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us