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Stochastic synchronization of interacting pathways in testosterone model

Paper ID Volume ID Publish Year Pages File Format Full-Text
15157 1383 2012 8 PDF Available
Title
Stochastic synchronization of interacting pathways in testosterone model
Abstract

We examine the possibilities of various coupling mechanisms among a group of identical stochastic oscillators via Chemical Langevin formalism where each oscillator is modeled by stochastic model of testosterone (T) releasing pathway. Our results show that the rate of synchrony among the coupled oscillators depends on various parameters namely fluctuating factor, coupling constants ϵ, and interestingly on system size. The results show that synchronization is achieved much faster in classical deterministic system rather than stochastic system. Then we do large scale simulation of such coupled pathways using stochastic simulation algorithm and the detection of synchrony is measured by various order parameters such as synchronization manifolds, phase plots etc and found that the proper synchrony of the oscillators is maintained in different coupling mechanisms and support our theoretical claims. We also found that the coupling constant follows power law behavior with the systems size (V) by ϵ ∼ AV−γ, where γ = 1 and A is a constant. We also examine the phase transition like behavior in all coupling mechanisms that we have considered for simulation. The behavior of the system is also investigated at thermodynamic limit; where V→ ∞, molecular population, N→ ∞ but NV→finite, to see the role of noise in information processing and found the destructive role in the rate of synchronization.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The possible coupling mechanism in the interacting pathways of testosterone hormone is studied theoretically. ► We found coupling constant to follow power law behavior with system size showing the effect of noise in it. ► The destructive role of noise at small system size is seen giving hindrance to synchronization. ► Delay induced synchronization of the interacting pathways is identified in this model.

Keywords
Cell signaling; Synchronization; Coupling; Intercellular communication; Intracellular communication
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 41, December 2012, Pages 10–17
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us