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Pharmacokinetic analysis of multi PEG–theophylline conjugates

Paper ID Volume ID Publish Year Pages File Format Full-Text
15174 1385 2012 8 PDF Available
Title
Pharmacokinetic analysis of multi PEG–theophylline conjugates
Abstract

In the attempt of prolonging the effect of drugs, a new branched, high-molecular weight multimeric poly(ethylene glycol) (MultiPEG), synthesized with a simple assembling procedure that devised the introduction of functional groups with divergent and selective reactivity, was employed as drug carrier. In particular, the attention was focused on the study of theophylline (THEO) and THEO-MultiPEG conjugates pharmacokinetic after oral administration in rabbit. Pharmacokinetic behavior was studied according to an ad hoc developed mathematical model accounting for THEO-MultiPEG in vivo absorption and decomposition into drug (THEO) and carrier (MultiPEG). The branched high-molecular weight MultiPEG proved to be a reliable drug delivery system able to prolong theophylline staying in the blood after oral administration of a THEO-MultiPEG solution. The analysis of experimental data by means of the developed mathematical model revealed that the prolongation of THEO effect was essentially due to the low THEO-MultiPEG permeability in comparison to that of pure THEO.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlight► Prolonged theophylline effect if administered as a multimeric PEG-drug solution. ► Reliable mathematical model for the PK data interpretation. ► Multimeric PEG-theophylline decomposition occurs after GI mucosa crossing. ► Prolonged theophylline effect is mainly due to conjugate permeability reduction.

Keywords
Pharmacokinetic; Mathematical modeling; MultiPEG
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Pharmacokinetic analysis of multi PEG–theophylline conjugates
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 40, October 2012, Pages 7–14
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us