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Tracing the evolution of the mitochondrial protein import machinery

Paper ID Volume ID Publish Year Pages File Format Full-Text
15189 1389 2011 5 PDF Available
Title
Tracing the evolution of the mitochondrial protein import machinery
Abstract

Mitochondria are eukaryotic organelles originated from a single bacterial endosymbiosis about 2 billion years ago. One of the earliest events in the evolution of mitochondria was the acquisition of a mechanism that facilitated the import of proteins from cytosol. The mitochondrial protein import machinery consists of dozens of subunits, and they are of modular design. However, to date, it is not clear when certain component was added to the machinery. Using extensive homology searches, the evolutionary history of the mitochondrial protein import machinery was reconstructed. The results indicated that 6 of the 35 subunits have homologs in prokaryote, suggesting that they were prokaryotic origin; the major subunit gains were occurred in the earliest stage of eukaryotic evolution; subsequent to the gain of these conserved set of subunits, the mitochondrial protein import machinery components diversified along the eukaryotic lineages and a number of lineage-specific subunits can be observed. Furthermore, protein import systems of mitochondria-like organelles (hydrogenosomes and mitosomes) have dramatically reduced their subunit contents, however, they share most of the prokaryotic origin components with mitochondrion.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► 6 subunits have homologs in prokaryote. ► Major subunits gains occurred in the earliest stage of eukaryotic evolution. ► Mitochondria-like organelles share most of the prokaryotic origin components.

Keywords
Mitochondria; Protein import; Molecular evolution; Homology
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 35, Issue 6, 14 December 2011, Pages 336–340
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us