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The challenge of annotating protein sequences: The tale of eight domains of unknown function in Pfam

Paper ID Volume ID Publish Year Pages File Format Full-Text
15221 1392 2010 5 PDF Available
Title
The challenge of annotating protein sequences: The tale of eight domains of unknown function in Pfam
Abstract

The Pfam database is an important tool in genome annotation, since it provides a collection of curated protein families. However, a subset of these families, known as domains of unknown function (DUFs), remains poorly characterized. We have related sequences from DUF404, DUF407, DUF482, DUF608, DUF810, DUF853, DUF976 and DUF1111 to homologs in PDB, within the midnight zone (9–20%) of sequence identity. These relationships were extended to provide functional annotation by sequence analysis and model building. Also described are examples of residue plasticity within enzyme active sites, and change of function within homologous sequences of a DUF.

Keywords
Sequence homology; Function prediction; Pfam; Domains of unknown function
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The challenge of annotating protein sequences: The tale of eight domains of unknown function in Pfam
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 34, Issue 3, June 2010, Pages 210–214
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us