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Effect of silicon content on the sintering and biological behaviour of Ca10(PO4)6-x(SiO4)x(OH)2-x ceramics

Paper ID Volume ID Publish Year Pages File Format Full-Text
1524 85 2009 10 PDF Available
Title
Effect of silicon content on the sintering and biological behaviour of Ca10(PO4)6-x(SiO4)x(OH)2-x ceramics
Abstract

Silicated hydroxyapatite powders (Ca10(PO4)6-x(SiO4)x(OH)2-x; SixHA) were synthesized using a wet precipitation method. The sintering of SixHA ceramics with 0 ⩽ x ⩽ 1 was investigated. For 0 ⩽ x ⩽ 0.5, the sintering rate and grain growth decreased slightly with the amount of silicate. For larger amounts, the sintering behaviour differed with the formation of secondary phases before total densification. Sintering parameters (temperature and time) were adjusted to each composition to produce dense materials having similar microstructure without formation of these secondary phases. Dense ceramics made of pure hydroxyapatite and SixHA containing various amounts of silicate (up to x = 0.6) were biologically tested in vitro with human osteoblast-like cells. The proliferation of cells on the surface of the ceramics increased up to 5 days of culture, indicating that the materials were biocompatible. However, the silicon content did not influence the cell proliferation.

Keywords
Silicated hydroxyapatite; Sintering; In vitro tests; Osteoblast-like cell; Proliferation
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Effect of silicon content on the sintering and biological behaviour of Ca10(PO4)6-x(SiO4)x(OH)2-x ceramics
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 4, May 2009, Pages 1223–1232
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us