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Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals

Paper ID Volume ID Publish Year Pages File Format Full-Text
1526 85 2009 12 PDF Available
Title
Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals
Abstract

Alanine, arginine and aspartic acid have been used as co-reagents during the synthesis of a biomimetic calcium-deficient hydroxyapatite (CDHA) for the synergistic coupling of synthesis and functionalization. The surface and bulk characterizations are consistent with a binding model in which the amino acid is preferentially bound to the CDHA nanocrystal surface by its lateral chain group. The ζ-potential measurements show that the amino acid-functionalized CDHA surface charge shifts towards neutral compared to CDHA synthesized in the absence of amino acids. Amino acids bound to the crystal induce crystal growth inhibition predominantly at the Ca-rich surfaces during the initial stages of crystallization. Moreover, high-resolution transmission electron microscopy measurements suggest a model for needle-shaped CDHA nanocrystals formation in the presence of either arginine or aspartic acid based on the oriented aggregation of primary crystallite domains specifically along the c-axis direction and the self-assembly of preformed nanoparticles. The results have significant importance for the control of the shape, morphology and aggregation of the CDHA nanocrystals, while the observed surface modifications are of marked importance for the nature, stability and reactivity of the functionalized surfaces produced.

Keywords
Hydroxyapatite; Amino acids; Surface functionality; Biomimetism; Nanocrystals
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Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 4, May 2009, Pages 1241–1252
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us