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Computer-assisted identification of small-molecule Bcl-2 modulators

Paper ID Volume ID Publish Year Pages File Format Full-Text
15274 1399 2009 6 PDF Available
Title
Computer-assisted identification of small-molecule Bcl-2 modulators
Abstract

Apoptosis, the programmed cell death, is a highly regulated process, necessary for normal development and homeostasis of the functions of organisms. The Bcl-2 inhibitors BH3I-1 and BH3I-2 were used as lead compounds to find possible Bcl-2 or Bcl-XL inhibitors by using computer-assisted screening with our in-house database, containing more than four million commercially available molecules. Identified compounds were further investigated regarding their possible application as a drug.

Keywords
Bcl-2; Apoptosis; Inhibitors; Computer-assisted screening
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 33, Issue 6, December 2009, Pages 451–456
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us