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Computation of direct and inverse mutations with the SEGM web server (Stochastic Evolution of Genetic Motifs): An application to splice sites of human genome introns

Paper ID Volume ID Publish Year Pages File Format Full-Text
15291 1401 2009 8 PDF Available
Title
Computation of direct and inverse mutations with the SEGM web server (Stochastic Evolution of Genetic Motifs): An application to splice sites of human genome introns
Abstract

We present here the SEGM web server (Stochastic Evolution of Genetic Motifs) in order to study the evolution of genetic motifs both in the direct evolutionary sense (past–present) and in the inverse evolutionary sense (present–past). The genetic motifs studied can be nucleotides, dinucleotides and trinucleotides. As an example of an application of SEGM and to understand its functionalities, we give an analysis of inverse mutations of splice sites of human genome introns. SEGM is freely accessible at http://lsiit-bioinfo.u-strasbg.fr:8080/webMathematica/SEGM/SEGM.html directly or by the web site http://dpt-info.u-strasbg.fr/~michel/. To our knowledge, this SEGM web server is to date the only computational biology software in this evolutionary approach.

Keywords
Stochastic evolution; Genetic motifs; Direct and inverse mutations; Evolutionary computation; Web server; Splice sites; Human genome introns
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Computation of direct and inverse mutations with the SEGM web server (Stochastic Evolution of Genetic Motifs): An application to splice sites of human genome introns
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 33, Issue 4, August 2009, Pages 245–252
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us