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Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo

Paper ID Volume ID Publish Year Pages File Format Full-Text
1533 85 2009 8 PDF Available
Title
Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo
Abstract

Protein adsorption affects the function of cells and determines the bioactivity of biomaterial implants. Surface structure and properties of materials determine the behavior of protein adsorption. In the present study, two biphasic calcium-phosphate ceramics (BCPs) with different surface structures were fabricated by pressing and H2O2 foaming methods. Their surface characteristics were analyzed and the in vitro and in vivo protein adsorption on them was investigated. Porous BCP showed higher ability to adsorb proteins, and transforming growth factor-β1 (TGF-β1) adsorption notably increased with increasing in vivo implantation time. The strong affinity of BCP to TGF-β1 might provide important information for exploring the mechanism of the osteoinduction of calcium phosphates.

Keywords
BCPs; Surface structure; Protein adsorption; TGF-β1
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Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 4, May 2009, Pages 1311–1318
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us