fulltext.study @t Gmail

Why have serine/threonine/tyrosine kinases been evolutionarily selected in eukaryotic signaling cascades?

Paper ID Volume ID Publish Year Pages File Format Full-Text
15333 1404 2008 4 PDF Available
Title
Why have serine/threonine/tyrosine kinases been evolutionarily selected in eukaryotic signaling cascades?
Abstract

The signal transduction systems of eukaryotes are different from those of prokaryotes with respect to their structures and mechanisms. The main signal transduction system of prokaryotes called the two-component system (TCS) is a one-step phosphorelay system composed of a histidine kinase (HK) while the central signal transduction system of eukaryotes called the mitogen-activated protein kinase (MAPK) cascade system (MCS) is a multi-step phosphorelay system composed of serine/threonine/tyrosine kinases (STYKs). The two signal transduction systems are also different in their transphosphorylation mechanisms. HK in the TCS transfers its own phosphate group to the response regulator protein while STYKs in the MCS phosphorylate other proteins using ATP. We were intrigued by the different dynamics resulting from such differences and wondered why STYKs instead of HKs have been evolutionarily selected in eukaryotic signaling cascades. In this paper, we compared the dynamical characteristics of two mathematical models which reflect such differences between the TCS and the MCS, and found that STYKs are more appropriate for cascade structures in eukaryotic signal transduction than HK with respect to the duration and settling time of response signals.

Keywords
MAPK, mitogen-activated protein kinase; MCS, MAPK cascade system; TCS, two-component system; STYK, serine/threonine/tyrosine kinase; HK, histidine kinaseSignal transduction; MAPK pathways; Two-component systems; Serine/threonine/tyrosine kinase; Histidine
First Page Preview
Why have serine/threonine/tyrosine kinases been evolutionarily selected in eukaryotic signaling cascades?
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 32, Issue 3, June 2008, Pages 218–221
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us