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The ambush hypothesis at the whole-organism level: Off frame, ‘hidden’ stops in vertebrate mitochondrial genes increase developmental stability

Paper ID Volume ID Publish Year Pages File Format Full-Text
15338 1405 2010 6 PDF Available
Title
The ambush hypothesis at the whole-organism level: Off frame, ‘hidden’ stops in vertebrate mitochondrial genes increase developmental stability
Abstract

Off frame reading of protein coding sequences reveals numerous stop codons. The genetic code and genomic codon usages maximize hidden stop numbers, minimizing effects of ribosomal slippages. This increases efficiency and homogeneity of protein expression. Here I test whether developmental stability in bilateral morphological traits of lizards and primates increases with numbers of hidden stops in mitochondrial protein coding genes. Expected effects are weak, but are apparent in 14 among 16 independent taxonomic groups for the non-coding +1 frame, and 12 among 16 for the −1 frame. Results stress that many molecular factors determine phenotypes in a complex manner, frequently undetectable by classical quantitative genetics. Explicit molecular hypotheses can partially palliate this shortcoming, and uncover unsuspected links between genotype and phenotype, especially when molecular epistasis (here interactions between hidden stops and ribosomes), is involved. Effects of hidden stops on morphological developmental stability suggest that mitochondrial off frame stops might also affect human cumulative neurodegenerative diseases. Results suggest adaptive rather than neutralist interpretations of the ambush hypothesis.

Keywords
Ribosomal slippage; Developmental instability; Fluctuating asymmetry; Bilateral symmetry; Subdigital lamellae; Genetic code optimization
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The ambush hypothesis at the whole-organism level: Off frame, ‘hidden’ stops in vertebrate mitochondrial genes increase developmental stability
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 34, Issue 2, April 2010, Pages 80–85
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us