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ProSTRIP: A method to find similar structural repeats in three-dimensional protein structures

Paper ID Volume ID Publish Year Pages File Format Full-Text
15344 1405 2010 5 PDF Available
Title
ProSTRIP: A method to find similar structural repeats in three-dimensional protein structures
Abstract

The occurrence of similar structural repeats in a protein structure has evolved through gene duplication. These repeats act as a structural building block and form more than one compact structural and functional unit called a repeat domain. The protein families comprising similar structural repeats are mainly involved in protein–protein interactions as well as binding to other ligand molecules. The identification of internal sequence repeats in the primary structure is not sufficient for the analysis of structural repeats. Thus, a new method called ProSTRIP has been developed using dynamic programming to find the similar structural repeats in a three-dimensional protein structure. The detection of these repeats is made by calculating the protein backbone Cα angles. An internet computing server is also created by implementing this method and enables graphical visualization of the results. It can be freely accessed at http://cluster.physics.iisc.ernet.in/prostrip/.

Keywords
Structural repeats; Gene duplication; Repeat domain; Protein–protein interactions; Dynamic programming
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ProSTRIP: A method to find similar structural repeats in three-dimensional protein structures
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 34, Issue 2, April 2010, Pages 126–130
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us