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Stochastic protein folding simulation in the three-dimensional HP-model

Paper ID Volume ID Publish Year Pages File Format Full-Text
15350 1406 2008 8 PDF Available
Title
Stochastic protein folding simulation in the three-dimensional HP-model
Abstract

We present results from three-dimensional protein folding simulations in the HP-model on ten benchmark problems. The simulations are executed by a simulated annealing-based algorithm with a time-dependent cooling schedule. The neighbourhood relation is determined by the pull-move set. The results provide experimental evidence that the maximum depth D   of local minima of the underlying energy landscape can be upper bounded by D

Keywords
Protein folding; HP-model; Landscape analysis; Stochastic local search; Simulated annealing
First Page Preview
Stochastic protein folding simulation in the three-dimensional HP-model
Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 32, Issue 4, August 2008, Pages 248–255
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering