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Prediction of Alzheimer's diagnosis using semi-supervised distance metric learning with label propagation

Paper ID Volume ID Publish Year Pages File Format Full-Text
15368 1407 2008 4 PDF Available
Title
Prediction of Alzheimer's diagnosis using semi-supervised distance metric learning with label propagation
Abstract

Alzheimer's disease (AD) is the most common form of dementia and leads to irreversible neurogenerative damage of the brain. However, the current diagnostic tools have poor sensitivity, especially for the early stages of AD and do not allow for diagnosis until AD has lead to irreversible brain damage. Therefore, it is crucial that AD is detected as early as possible. Although it is very hard, laborious and time-consuming to gather many AD and non-AD labeled samples, gathering unlabeled samples is easier than labeled samples. Since standard learning algorithms learn a diagnosis model from labeled samples only, they require many labeled samples and do not work well when the number of training samples is small. Therefore, it is very desirable to develop a predictive learning method to achieve high performance using both labeled samples and unlabeled samples. To address these problems, we propose semi-supervised distance metric learning using Random Forests with label propagation (SRF-LP) which incorporates labeled data for obtaining good metrics and propagates labels based on them. Experimental results showed that SRF-LP outperformed standard supervised learning algorithms, i.e., RF, SVM, Adaboost and CART and reached 93.1% accuracy at a maximum. Especially, SRF-LP largely outperformed when the number of training samples is very small. Our results also suggested that SRF-LP exhibits a synergistic effect of semi-supervised distance metric learning and label propagation.

Keywords
Alzheimer's disease; Diagnosis; Semi-supervised learning; Distance metric learning; Label propagation
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Prediction of Alzheimer's diagnosis using semi-supervised distance metric learning with label propagation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 32, Issue 6, December 2008, Pages 438–441
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us