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Applications of domain–domain interactions in pathway study

Paper ID Volume ID Publish Year Pages File Format Full-Text
15387 1409 2008 7 PDF Available
Title
Applications of domain–domain interactions in pathway study
Abstract

The domain combination pair approach is employed to derive putative protein domain–domain interactions (DDI) from the protein–protein interactions (PPI) database DIP. The results of putative DDI are computed for seven species. To determine the prediction performance, putative DDI results are compared with that of the database InterDom, where an average matching ratio of about 76% can be achieved.Several real PPI pathways are reconstructed based on the predicted DDI results. It is found that the pathways could be reconstructed with reasonable accuracy. Furthermore, a novel quantity, so called AP-order index, is introduced to predict the regulatory order for six PPI pathways. It is found that the AP-order index is a very reliable parameter to determine the regulatory order of PPI.

Keywords
Protein–protein interaction; Domain–domain interaction; Chemotaxis pathway; Blood coagulation pathway; MAPK pathway; Entropy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 32, Issue 2, April 2008, Pages 81–87
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us