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A simple method of identifying symmetric substructures of proteins

Paper ID Volume ID Publish Year Pages File Format Full-Text
15434 1412 2009 8 PDF Available
Title
A simple method of identifying symmetric substructures of proteins
Abstract

Accurate identifications of internal symmetric substructures of proteins are needed in protein evolution study and protein design. To overcome the difficulties met by previous methods, here we propose a simple quantitative one by using a similarity matrix plus Pearson's correlation analysis. The distance root-mean-square deviation (dRMSD) is used to measure the similarity of two substructures in a protein. We applied this method to the proteins of the β-propeller, jelly roll, and β-trefoil families and the results show that this method cannot only detect the internal repetitive structures in proteins effectively, but also can identify their locations easily.

Keywords
Structural symmetry; dRMSD; Similarity matrix; Pearson's correlation
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A simple method of identifying symmetric substructures of proteins
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 33, Issue 1, February 2009, Pages 100–107
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us