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Mitochondrial SNPs associated with Japanese centenarians, Alzheimer's patients, and Parkinson's patients

Paper ID Volume ID Publish Year Pages File Format Full-Text
15474 1416 2008 6 PDF Available
Title
Mitochondrial SNPs associated with Japanese centenarians, Alzheimer's patients, and Parkinson's patients
Abstract

In this paper we examined the relations between three classes of people (96 Japanese centenarians, 96 Japanese Alzheimer's disease (AD) patients and 96 Japanese Parkinson's disease (PD) patients) and their mitochondrial single nucleotide polymorphism (mtSNP) frequencies at individual mitochondrial DNA (mtDNA) positions of the entire mt-genome by using the radial basis function (RBF) networks. As a result, we got new findings of mtSNPs for representing characteristics of individual classes. These mtSNPs show distinct differences for three classes of people. That is, individual classes of people are characterized by unique mtSNPs. Interestingly, Japanese centenarians are closely associated with haplogroup D4, Japanese AD patients with haplogroup G2a, and Japanese PD patients with haplogroup M7a. These characteristics of mtSNPs are different from those of previously reported works. As the amino acid replacement mtSNPs were at four mtDNA positions, it is indicated that mtSNPs of synonymous nucleotide substitutions as well as those of nonsynonymous nucleotide substitutions may play important roles in mitochondrial functions.

Keywords
Mitochondrial SNP; Association; Centenarian; Alzheimer's disease; Parkinson's disease; Haplogroup; Radial basis function (RBF)
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Mitochondrial SNPs associated with Japanese centenarians, Alzheimer's patients, and Parkinson's patients
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 32, Issue 5, October 2008, Pages 332–337
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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