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Software Note: Using probe secondary structure information to enhance Affymetrix GeneChip background estimates

Paper ID Volume ID Publish Year Pages File Format Full-Text
15489 1417 2007 7 PDF Available
Title
Software Note: Using probe secondary structure information to enhance Affymetrix GeneChip background estimates
Abstract

High-density short oligonucleotide microarrays are a primary research tool for assessing global gene expression. Background noise on microarrays comprises a significant portion of the measured raw data. A number of statistical techniques have been developed to correct for this background noise. Here, we demonstrate that probe minimum folding energy and structure can be used to enhance a previously existing model for background noise correction. We estimate that probe secondary structure accounts for up to 3% of all variation on Affymetrix microarrays.

Keywords
DNA microarray; Probe secondary structure; Background correction
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Software Note: Using probe secondary structure information to enhance Affymetrix GeneChip background estimates
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 31, Issue 2, April 2007, Pages 92–98
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us