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Solution for underflow problem in linkage and segregation analysis

Paper ID Volume ID Publish Year Pages File Format Full-Text
15521 1420 2006 4 PDF Available
Title
Solution for underflow problem in linkage and segregation analysis
Abstract

Finding genes for complex traits is one of the major challenges of modern human genetics. Current developments of molecular techniques facilitated use of large pedigrees and marker sets of thousands of single-nucleotide polymorphisms (SNPs). However, one of the problems occurring in statistical analysis of such large data sets is that the likelihood is very low and underflow may easily occur.In this work we describe a method permitting to avoid underflow during computation of a likelihood function, using different algorithms. Our method makes practically possible analysis of thousands of individuals and thousands of SNPs. The method is easy to implement without major change of the code of existing programs. It also helps to reduce the amount of computer memory used in analysis without noticeable alteration of the program running time.The algorithm was implemented in the software packages for segregation and linkage analysis, which are available from http://mga.bionet.nsc.ru/.

Keywords
Genetic analysis; Peeling; Likelihood; Underflow
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Solution for underflow problem in linkage and segregation analysis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 30, Issue 5, October 2006, Pages 382–385
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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