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Genome-wide computational analyses of microRNAs and their targets from Canis familiaris

Paper ID Volume ID Publish Year Pages File Format Full-Text
15533 1421 2008 6 PDF Available
Title
Genome-wide computational analyses of microRNAs and their targets from Canis familiaris
Abstract

By computational analyses, we identified 357 miRNA candidates from Canis familiaris genome, among which 300 are homology of characterized human miRNAs, the remains are not reported in any other animal. Of the 357 miRNA genes, 142 are organized into 53 clusters, and two clusters locate in the paternally imprinted region. These dog miRNAs may regulate more than 800 possible targets, which are involved in a wide range of cellular processes. Remarkably, miR-186 resides in the eighth intron of its target gene in the same orientation, suggesting a feedback regulation of miRNA on its host gene.

Keywords
UTR, un-translated region; LINE, long interspersed nuclear element; SINE, short interspersed nuclear element; nt, nucleotidemiRNA; Canis familiaris; Computational analyses; Paralogus cluster
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Genome-wide computational analyses of microRNAs and their targets from Canis familiaris
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Publisher
Database: Elsevier - ScienceDirect
Journal: Computational Biology and Chemistry - Volume 32, Issue 1, February 2008, Pages 61–66
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us