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Progress and challenges in the engineering of non-cellulolytic microorganisms for consolidated bioprocessing

Paper ID Volume ID Publish Year Pages File Format Full-Text
15602 42454 2015 7 PDF Available
Title
Progress and challenges in the engineering of non-cellulolytic microorganisms for consolidated bioprocessing
Abstract

•Consolidated bioprocessing is a promising technology to enable cellulose utilization.•Yeast, filamentous fungi and bacteria have been engineered as CBP organisms.•Heterologous free enzymes, cell surface engineering and minicellulosomes were used.•All candidate organisms require further optimization of cellulolytic activity.•Process hardening of CBP organisms is a priority that cannot be overlooked.

Lignocellulosic biomass is an abundant, renewable feedstock for the production of fuels and chemicals, if an efficient and affordable conversion technology can be established to overcome its recalcitrance. Consolidated bioprocessing (CBP) featuring enzyme production, substrate hydrolysis and fermentation in a single step is a biologically mediated conversion approach with outstanding potential if a fit-for-purpose microorganism(s) can be developed. Progress in developing CBP-enabling microorganisms is ongoing by engineering (i) naturally cellulolytic microorganisms for improved product-related properties or (ii) non-cellulolytic organisms exhibiting high product yields to heterologously produce different combinations of cellulase enzymes. We discuss progress on developing yeast and bacteria for the latter strategy and consider further challenges that require attention to bring this technology to market.

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Progress and challenges in the engineering of non-cellulolytic microorganisms for consolidated bioprocessing
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 33, June 2015, Pages 32–38
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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