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Activity-based proteomic and metabolomic approaches for understanding metabolism

Paper ID Volume ID Publish Year Pages File Format Full-Text
15632 42462 2014 11 PDF Available
Title
Activity-based proteomic and metabolomic approaches for understanding metabolism
Abstract

•There are many enzymatic pathways that remain uncharacterized in the human genome.•Activity-based proteomics globally assesses enzyme activities.•Activity-based proteomics can be used for inhibitor discovery of enzymes.•Metabolomics can dissect enzyme function in complex living systems.

There are an increasing number of human pathologies that have been associated with altered metabolism, including obesity, diabetes, atherosclerosis, cancer, and neurodegenerative diseases. Most attention on metabolism has been focused on well-understood metabolic pathways and has largely ignored most of the biochemical pathways that operate in (patho)physiological settings, in part because of the vast landscape of uncharacterized and undiscovered metabolic pathways. One technology that has arisen to meet this challenge is activity-based protein profiling (ABPP) that uses activity-based chemical probes to broadly assess the functional states of both characterized and uncharacterized enzymes. This review will focus on how ABPP, coupled with inhibitor discovery platforms and functional metabolomic technologies, have led to discoveries that have expanded our knowledge of metabolism in health and disease.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 28, August 2014, Pages 116–126
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us