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Nucleic acids for the rational design of reaction circuits

Paper ID Volume ID Publish Year Pages File Format Full-Text
15644 42465 2013 6 PDF Available
Title
Nucleic acids for the rational design of reaction circuits
Abstract

Nucleic acid-based circuits are rationally designed in vitro assemblies that can perform complex preencoded programs. They can be used to mimic in silico computations. Recent works emphasized the modularity and robustness of these circuits, which allow their scaling-up. Another new development has led to dynamic, time-responsive systems that can display emergent behaviors like oscillations. These are closely related to biological architectures and provide an in vitro model of in vivo information processing. Nucleic acid circuits have already been used to handle various processes for technological or biotechnological purposes. Future applications of these chemical smart systems will benefit from the rapidly growing ability to design, construct, and model nucleic acid circuits of increasing size.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (122 K)Download as PowerPoint slideHighlights► Nucleic acids can be used to build reaction modules modeled after in vivo or in silico computers. ► In vitro circuits built from these modules perform one-shot calculations or show complex dynamics. ► Applications at the interface with biology, or for molecular-scale robotics, are burgeoning.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 575–580
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
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