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Engineering enzymatic cascades on nanoscale scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
15648 42465 2013 6 PDF Available
Title
Engineering enzymatic cascades on nanoscale scaffolds
Abstract

Scaffold proteins are involved in many enzyme cascades in signaling pathways and metabolic processes. The study of scaffolds occurring in biological systems advances at a rapid pace and recently developed engineered synthetic scaffolds enable the precise placement of components of an enzymatic cascade within nanometer distances. Recent experimental results demonstrate significantly increased throughput of enzymatic cascades as a result of the utilization of a scaffold, but our understanding of the mechanisms responsible for this increase is not complete. We discuss the physics of diffusive transport processes relevant for these unique reaction–diffusion systems.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (147 K)Download as PowerPoint slideHighlights► Scaffold proteins play an important role in biological enzymatic cascades. ► Novel engineered scaffolds have allowed construction of artificial enzymatic cascades. ► Diffusive transport of substrate molecules and spatial constraints impact cascade kinetics and scaffold contribution.

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Engineering enzymatic cascades on nanoscale scaffolds
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 606–611
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us