fulltext.study @t Gmail

Reengineering viruses and virus-like particles through chemical functionalization strategies

Paper ID Volume ID Publish Year Pages File Format Full-Text
15650 42465 2013 7 PDF Available
Title
Reengineering viruses and virus-like particles through chemical functionalization strategies
Abstract

Increasing demands from nanotechnology require increasingly more rigorous methods to control nanoparticle traits such as assembly, size, morphology, monodispersity, stability, and reactivity. Viruses are a compelling starting point for engineering nanoparticles, as eons of natural biological evolution have instilled diverse and desirable traits. The next step is to reengineer these viruses into something functional and useful. These reengineered particles, or virus-based nanoparticles (VNPs), are the foundation for many promising new technologies in drug delivery, targeted delivery, vaccines, imaging, and biocatalysis. To achieve these end goals, VNPs must often be manipulated genetically and post-translationally. We review prevailing strategies of genetic and noncovalent functionalization and focus on the covalent modifications using natural and unnatural amino acid residues.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (128 K)Download as PowerPoint slideHighlights► Virus-based nanoparticles provide unique traits for nanoparticle applications. ► We discuss prevailing covalent functionalization strategies for VNPs. ► We discuss recent progress in noncanonical amino acid applications in VNPs.

First Page Preview
Reengineering viruses and virus-like particles through chemical functionalization strategies
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 620–626
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering