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Semi-synthetic minimal cells: origin and recent developments

Paper ID Volume ID Publish Year Pages File Format Full-Text
15652 42465 2013 6 PDF Available
Title
Semi-synthetic minimal cells: origin and recent developments
Abstract

The notion of minimal cells refers to cellular structures that contain the minimal and sufficient complexity to still be defined as living, or at least capable to display the most important features of biological cells. Here we briefly describe the laboratory construction of minimal cells, a project within the broader field of synthetic biology. In particular we discuss the advancements in the preparation of semi-synthetic cells based on the encapsulation of biochemicals inside liposomes, illustrating from the one hand the origin of this research and the most recent developments; and from the other the difficulties and limits of the approach. The role of physicochemical understandings is greatly emphasized.

Graphical abstractSemi-synthetic minimal cells are constructed by encapsulating the minimal number of nucleic acids, enzymes and low molecular-weight compounds inside lipid vesicles (liposomes) in order to create a cell-like system.Figure optionsDownload full-size imageDownload high-quality image (136 K)Download as PowerPoint slideHighlights► Minimal synthetic cells are used in origin of life studies and synthetic biology. ► The semi-synthetic approach is based on cell-free and liposome technology. ► Solutes can be super-encapsulated inside vesicles against the expectations. ► There have been new attempts to construct self-reproducing synthetic cells. ► Vesicle fusion and vesicle colonies emphasize the importance of cooperation.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 633–638
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us