fulltext.study @t Gmail

Nano-sized polymers and liposomes designed to deliver combination therapy for cancer

Paper ID Volume ID Publish Year Pages File Format Full-Text
15658 42465 2013 8 PDF Available
Title
Nano-sized polymers and liposomes designed to deliver combination therapy for cancer
Abstract

•Novel nanotechnologies emerging for combination therapy.•Combination nanomedicines in clinical trials: SNALP lipid particles bearing 2 siRNA.•Rational design: combined drug–drug, drug–peptide, drug–RNAi, RNAi–RNAi nanomedicines.•Future directions: Selection of drugs, loading ratio and characterization techniques.

The standard of care for cancer patients comprises more than one therapeutic agent. Treatment is complex since several drugs, administered by different routes, need to be coordinated, taking into consideration their side effects and mechanisms of resistance. Drug delivery systems (DDS), such as polymers and liposomes, are designed to improve the pharmacokinetics and efficacy of bioactive agents (drugs, proteins or oligonucleotides), while reducing systemic toxicity. Using DDS for co-delivery of several agents holds great potential since it targets simultaneously synergistic therapeutic agents increasing their selective accumulation at the tumor site and enhancing their activity allowing administration of lower doses of each agent, thus reducing their side effects. Taken together, implementation of smart DDS will hopefully result in increased patient's compliance and better outcome. This review will focus on the latest developments of combination therapy for cancer using DDS.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (215 K)Download as PowerPoint slide

First Page Preview
Nano-sized polymers and liposomes designed to deliver combination therapy for cancer
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 682–689
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us