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Biomolecular magic-angle spinning solid-state NMR: recent methods and applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
15661 42465 2013 11 PDF Available
Title
Biomolecular magic-angle spinning solid-state NMR: recent methods and applications
Abstract

The link of structure and dynamics of biomolecules and their complexes to their function and to many cellular processes has driven the quest for their detailed characterization by a variety of biophysical techniques. Magic-angle spinning solid-state nuclear magnetic resonance spectroscopy provides detailed information on the structural properties of such systems and in particular contributes invaluable information on non-soluble, large molecular-weight and non-crystalline biomolecules. This review summarizes the recent progress that has been made in the characterization of macromolecular assemblies, viruses, membrane proteins, amyloid fibrils, protein aggregates and more by magic-angle spinning solid-state NMR.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (371 K)Download as PowerPoint slideHighlights► Recent progress in biomolecular magic angle spinning solid state NMR is reviewed. ► MAS NMR is applied to study non-crystalline, non-soluble and high molecular-weight systems. ► New methods rely on sparse isotope enrichment, proton detection, fast spinning and signal enhancements. ► New structure calculations are based on 1H–1H restraints, paramagnetic effects and tensor analysis. ► Applications to protein aggregates, assemblies, fibrils, membrane proteins and enzymes are described.

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Biomolecular magic-angle spinning solid-state NMR: recent methods and applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 705–715
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us