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Integrative avenues for exploring the dynamics and evolution of protein interaction networks

Paper ID Volume ID Publish Year Pages File Format Full-Text
15670 42465 2013 9 PDF Available
Title
Integrative avenues for exploring the dynamics and evolution of protein interaction networks
Abstract

Over the past decade, the study of protein interaction networks (PINs) has shed light on the organizing principles of living cells. However, PINs have been mostly mapped in one single condition. We outline three of the most promising avenues of investigation in this field, namely the study of first, how PINs are rewired by mutations and environmental perturbations; secondly, how inter-species interactions affect PIN achitectures; thirdly, what mechanisms and forces drive PIN evolution. These investigations will unravel the dynamics and condition dependence of PINs and will thus lead to a better functional annotation of network architecture. One major challenge to reach these goals is the integration of PINs with other cellular regulatory networks in the context of complex cellular phenotypes.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (177 K)Download as PowerPoint slideHighlights► PINs are moving from static descriptions to a functional mechanistic understanding. ► Genetic and environmental perturbation studies provide functional knowledge of PINs. ► Interspecies interactions of PINs give insights into PIN regulation and evolution. ► Understanding PIN evolution requires taking into account non-adaptive forces. ► Unfolding PIN function requires integration of data from all organizational levels.

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Integrative avenues for exploring the dynamics and evolution of protein interaction networks
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 775–783
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering