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Building robust functionality in synthetic circuits using engineered feedback regulation

Paper ID Volume ID Publish Year Pages File Format Full-Text
15672 42465 2013 7 PDF Available
Title
Building robust functionality in synthetic circuits using engineered feedback regulation
Abstract

The ability to engineer novel functionality within cells, to quantitatively control cellular circuits, and to manipulate the behaviors of populations, has many important applications in biotechnology and biomedicine. These applications are only beginning to be explored. In this review, we advocate the use of feedback control as an essential strategy for the engineering of robust homeostatic control of biological circuits and cellular populations. We also describe recent works where feedback control, implemented in silico or with biological components, was successfully employed for this purpose.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (237 K)Download as PowerPoint slideHighlights► Engineered feedback loops implement elaborate functionality in synthetic circuits. ► The homeostatic potential of feedback loops is under-utilized in synthetic biology. ► Feedback control of engineered or natural cellular functions can be achieved using biological components or in silico regulation. ► Optogenetics and microfluidic technologies are important for implementing in silico control.

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Building robust functionality in synthetic circuits using engineered feedback regulation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 4, August 2013, Pages 790–796
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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Any Questions? feel free to contact us