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Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation

Paper ID Volume ID Publish Year Pages File Format Full-Text
1568 86 2008 9 PDF Available
Title
Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation
Abstract

We have previously studied the biocompatibility and mechanical properties of porous zein scaffolds. We based the study on the concept that composite scaffold materials, especially when combined with inorganic materials, are more suited to the mechanical and physiological demands of the host tissue than individual scaffold materials. We investigated the effect of zein/inorganic composite on the physical and biological properties of porous zein scaffolds, which were fabricated by salt-leaching. The composite was prepared by immersion in simulated body fluid. The hydroxyapatite (HA)-coated zein scaffold had the same porosity as the zein scaffold (over 75%). Using scanning electron microscopy, it was established that the morphology of pores located on the surface and within the porous scaffolds showed equally good pore interconnectivity with zein. However, the compressive Young’s modulus decreased from 240.1 ± 96.8 to 34.4 ± 12.6 MPa, and compressive strength decreased from 7.8 ± 1.2 to 4.2 ± 0.8 MPa. From the in vitro test with human bone marrow stroma cells, the osteoblastic differentiation on the surface of the HA-coated zein scaffold was increased, as expressed by the alkaline phosphatase activity and reverse transcription-polymerase chain reaction analysis for marker genes. From both the mechanical and biological evaluations, the HA-coated zein scaffold was found to be the optimal biomaterial for bone tissue engineering.

Keywords
Scaffold; Zein; Hydroxyapatite; Mechanical properties; Osteogenic
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Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 4, Issue 5, September 2008, Pages 1360–1368
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us