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Metabolomics platforms for genome wide association studies—linking the genome to the metabolome

Paper ID Volume ID Publish Year Pages File Format Full-Text
15684 42468 2013 9 PDF Available
Title
Metabolomics platforms for genome wide association studies—linking the genome to the metabolome
Abstract

Genome-wide association studies (GWAS) reveal links between genetic variance and predisposition to disease. With the advent of modern ‘omics-technologies’, GWAS can now identify the genetic factors that influence intermediate traits on pathways to disease, such as blood concentrations of carbohydrates, lipids, amino acids, and secondary metabolites, hormones and signal molecules. At the example of recent GWAS with metabolic traits (mGWAS) we review the high-throughput screening approaches that are available to further advance the field.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (162 K)Download as PowerPoint slideHighlights► Genome-wide association studies with metabolomics constitute mGWAS. ► mGWAS provide insights into genetic and environmental impact on metabolic processes. ► We review essential strategies for mGWAS. ► Examples of mGWAS in large cohort studies are discussed.

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Metabolomics platforms for genome wide association studies—linking the genome to the metabolome
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 1, February 2013, Pages 39–47
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us