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Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis

Paper ID Volume ID Publish Year Pages File Format Full-Text
15698 42470 2013 7 PDF Available
Title
Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis
Abstract

•Mechanical influences on tendon cells during embryonic development are reviewed.•Potential mechanisms of mechanotransduction in embryonic tendon cells are discussed.•Mechanoregulation strategies to induce tenogenesis of stem cells are examined.

Tendons are connective tissues required for motion and are frequently injured. Poor healing and inadequate return to normal tissue structure and mechanical function make tendon a prime candidate for tissue engineering; however functional tendons have yet to be engineered. The physical environment, from substrate stiffness to dynamic mechanical loading, may regulate tenogenic stem cell differentiation. Tissue stiffness and loading parameters derived from embryonic development may enhance tenogenic stem cell differentiation and tendon tissue formation. We highlight the current understanding of the mechanical environment experienced by embryonic tendons and how progenitor cells may sense and respond to physical inputs. We further discuss how mechanical factors have only recently been used to induce tenogenic fate in stem cells.

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Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 5, October 2013, Pages 834–840
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us