fulltext.study @t Gmail

Engineering synthetic hydrogel microenvironments to instruct stem cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
15699 42470 2013 6 PDF Available
Title
Engineering synthetic hydrogel microenvironments to instruct stem cells
Abstract

•Instructing stem cell function by mimicking the extracellular matrix.•Designing tunable network degradability and incorporating adhesive cues.•Tuning matrix mechanics and incorporating dynamic mechanical loading.•Presenting growth factors to stimulate cell signaling.

Advances in our understanding and ability to manipulate stem cell behavior are helping to move stem cell-based therapies toward the clinic. However, much of our knowledge has been gained from standard 2-dimensional culture systems, which often misrepresent many of the signals that stem cells receive in their native 3-dimensional environments. Fortunately, the field of synthetic hydrogels is developing to better recapitulate many of these signals to guide stem cell behavior, both as in vitro models and as delivery vehicles for in vivo implantation. These include a multitude of structural and biochemical cues that can be presented on the cellular scale, such as degradation, adhesion, mechanical signals, topography, and the presentation of growth factors, often with precise spatiotemporal control.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (293 K)Download as PowerPoint slide

First Page Preview
Engineering synthetic hydrogel microenvironments to instruct stem cells
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 5, October 2013, Pages 841–846
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us