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Matrix-based gene delivery for tissue repair

Paper ID Volume ID Publish Year Pages File Format Full-Text
15701 42470 2013 9 PDF Available
Title
Matrix-based gene delivery for tissue repair
Abstract

•We present a detailed description of gene loaded scaffold design for tissue repair.•Infiltrating cells are transfected through released DNA or matrix residing DNA.•Surface associated DNA via nonspecific adsorption is a popular current technique.•Biochemical cues may be used to ‘prime’ cells for transgene expression.

Scaffolds for tissue repair must provide structural and biochemical cues to initiate the complex cascade of events that lead to proper tissue formation. Incorporating genes into these scaffolds is an attractive alternative to protein delivery since gene delivery can be tunable to any DNA sequence and genes utilize the cells’ machinery to continuously produce therapeutic proteins, leading to longer lasting transgene expression and activation of autocrine and paracrine signaling that are not activated with bulk protein delivery. In this review, we discuss the importance of scaffold design and the impact of its design parameters (e.g. material, architecture, vector incorporation, biochemical cue presentation) on transgene expression and tissue repair.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 5, October 2013, Pages 855–863
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us