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Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs

Paper ID Volume ID Publish Year Pages File Format Full-Text
15703 42470 2013 8 PDF Available
Title
Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs
Abstract

•Efforts to repair intervertebral disc are targeted at annulus fibrosus and nucleus pulposus, both alone and in combination.•Tissue integration and mechanical competence are key factors for assessing functionality of repair and regeneration.•Key gaps in knowledge arise in areas of understanding efficacy of these repair strategies in vivo.

Advanced intervertebral disc (IVD) degeneration, a major cause of back pain in the United States, is treated using invasive surgical intervention which may cause further degeneration is the future. Because of the limitations of traditional solutions, tissue engineering therapies have become increasingly popular. IVDs have two distinct regions, the inner nucleus pulposus (NP) which is jelly-like and rich in glycosaminoglycans (GAGs) and the outer annulus fibrosus (AF) which is organized into highly collagenous lamellae. Tissue engineered scaffolds, as well as whole organ culture systems have been developed. These culture systems may help elucidate the initial causes of disc degeneration. To create an effective tissue engineered therapy, researchers have focused on designing materials that mimic the properties of these two regions to be used independently or in concert. The few in vivo studies show promise in retaining disc height and MRI T2 signal intensity, the gold standard in determining disc health.

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Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 5, October 2013, Pages 872–879
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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