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Engineering a local microenvironment for pancreatic islet replacement

Paper ID Volume ID Publish Year Pages File Format Full-Text
15707 42470 2013 9 PDF Available
Title
Engineering a local microenvironment for pancreatic islet replacement
Abstract

•Development of 3D niches to support islet engraftment and retain function.•Incorporation of native ECM proteins minimize islet anoikis.•Islet grafts benefit from recent advancements in strategies to supplement oxygen.•Bioactive materials facilitate and accelerate vascularization for islet implants.

Intraportal islet transplantation has emerged as a promising treatment for type 1 diabetes mellitus (T1DM). Nevertheless, long-term efficacy has been limited to a marginal number of patients. Outcomes have been restricted, in part, by challenges associated with the transplant site, poor vascularization, and disruption of the native islet architecture during the isolation process. Engineering a biomaterial platform that recapitulates critical components of the pancreatic environment can serve to address these hurdles. This review highlights the challenges and opportunities in engineering 3D niches for islets, specifically: the importance of site selection; the application of scaffold functionalization to present bioactive motifs; and the development of technologies for enhancing implant nutritional profiles. The potential of these novel approaches to improve islet engraftment and duration of function is discussed.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 5, October 2013, Pages 900–908
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us