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Quantitative approaches to uncover physical mechanisms of tissue morphogenesis

Paper ID Volume ID Publish Year Pages File Format Full-Text
15714 42470 2013 8 PDF Available
Title
Quantitative approaches to uncover physical mechanisms of tissue morphogenesis
Abstract

•Physical forces and the mechanical environment generate tissue form.•A series of tools are used to quantify cellular motions, deformations, and forces.•Imaging and cell tracking advancements define the kinetics of morphogenesis.•Invertebrate and culture models elucidate cellular forces that drive morphogenesis.•Computational models describe and predict experimentally observed behaviors.

Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.

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Quantitative approaches to uncover physical mechanisms of tissue morphogenesis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 24, Issue 5, October 2013, Pages 954–961
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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