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Polymer therapeutics as nanomedicines: new perspectives

Paper ID Volume ID Publish Year Pages File Format Full-Text
15722 42471 2011 10 PDF Available
Title
Polymer therapeutics as nanomedicines: new perspectives
Abstract

A growing number of polymer therapeutics have entered routine clinical use as nano-sized medicines. Early products were developed as anticancer agents, but treatments for a range of diseases and different routes of administration have followed – recently the PEGylated-anti-TNF Fab Cimzia® for rheumatoid arthritis and the PEG-aptamer Macugen® for age related macular degeneration. New polymer therapeutic concepts continue to emerge with a growing number of conjugates entering clinical development, for example PEGylated-aptamers and a polymer-based siRNA delivery system. ‘Hot’ topics of the past 2 years include; emerging issues relating to polymer safety, the increasing use of biodegradable polymers, design of technologies for combination therapy, potential biomarkers for patient individualisation of treatment and Regulatory challenges for ‘follow-on/generic’ polymer therapeutics.

► New polymer therapeutics entering clinical use include Cimzia®, Macugen® and Puricase®. ► Novel technologies emerging for combination therapy. ► Polymer therapeutic biomarkers will enable patient individualisation of treatment.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 4, August 2011, Pages 492–501
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
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