fulltext.study @t Gmail

Micro/nanofabricated environments for synthetic biology

Paper ID Volume ID Publish Year Pages File Format Full-Text
15725 42471 2011 11 PDF Available
Title
Micro/nanofabricated environments for synthetic biology
Abstract

A better understanding of how confinement, crowding and reduced dimensionality modulate reactivity and reaction dynamics will aid in the rational and systematic discovery of functionality in complex biological systems. Artificial microfabricated and nanofabricated structures have helped elucidate the effects of nanoscale spatial confinement and segregation on biological behavior, particularly when integrated with microfluidics, through precise control in both space and time of diffusible signals and binding interactions. Examples of nanostructured interfaces for synthetic biology include the development of cell-like compartments for encapsulating biochemical reactions, nanostructured environments for fundamental studies of diffusion, molecular transport and biochemical reaction kinetics, and regulation of biomolecular interactions as functions of microfabricated and nanofabricated topological constraints.

► Nanostructures function as artificial interfaces for synthetic biology. ► Nanostructures elucidate effects of spatial confinement and segregation on biological behavior. ► This review describes recent in vitro synthetic biology platforms enabled by nanofabrication.

First Page Preview
Micro/nanofabricated environments for synthetic biology
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 4, August 2011, Pages 516–526
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering