fulltext.study @t Gmail

Regulation and control of metabolic fluxes in microbes

Paper ID Volume ID Publish Year Pages File Format Full-Text
15733 42471 2011 10 PDF Available
Title
Regulation and control of metabolic fluxes in microbes
Abstract

After about ten years of research renaissance in metabolism, the present challenge is to understand how metabolic fluxes are controlled by a complex interplay of overlapping regulatory mechanisms. Reconstruction of various regulatory network topologies is steaming, illustrating that we underestimated the broad importance of post-translational modifications such as enzyme phosphorylation or acetylation for microbial metabolism. With the growing topological knowledge, the functional relevance of these regulatory events becomes an even more pressing need. A major knowledge gap resides in the regulatory network of protein–metabolite interactions, simply because we lacked pertinent methods for systematic analyses – but a start has now been made. Perhaps most dramatic was the conceptual shift in our perception of metabolism from an engine of cellular operation to a generator of input and feedback signals for regulatory circuits that govern many important decisions on cell proliferation, differentiation, death, and naturally metabolism.

► Overlapping regulatory mechanisms control metabolic fluxes. ► Post-translational modifications are abundant regulators of microbial metabolism. ► Input–output regulatory functions are most advanced for transcriptional networks. ► Metabolic feedback into regulatory networks governs many cellular decisions. ► Kinetic models are crucial to turn data into understanding of metabolic control.

First Page Preview
Regulation and control of metabolic fluxes in microbes
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Current Opinion in Biotechnology - Volume 22, Issue 4, August 2011, Pages 566–575
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us